Structural characterization and analysis of Omalizumab and its biosimilar CMAB007 by LC-MSChinese Full TextEnglish Full Text (MT)
Jun Xu;Dapeng Zhang;Hao Wang;Huaizu Guo;Shanghai Zhangjiang Biotechnology Co., Ltd.;School of Life Sciences, Fudan University;State Key Laboratory of Antibody Medicine and Targeted Therapy;
Abstract: We compared the similarity of Omalizumab（Xolair; a humanized anti-immunoglobulin E monoclonal antibody） and it’s biosimilar CMAB007. An in depth characterization of a candidate biosimilar was carried out using a systematic approach, the approach provides a set of routine tools that combine accurate intact mass measurement, peptide mapping, and released glycan profiling. CMAB007 and Omalizumab had the same primary structure and exhibited almost the same content of C-terminal lysine variants. The ... More
Keywords：
monoclonal antibody; Omalizumab; asthma; liquid chromatography mass spectrometry; biosimilar;
- DOI：
10.13345/j.cjb.150339
- Series：
(A) Mathematics/ Physics/ Mechanics/ Astronomy; (B) Chemistry/ Metallurgy/ Environment/ Mine Industry; (E) Medicine ＆ Public Health
- Subject：
Chemistry; Pharmaceutics
- Classification Code：
R917;O657.63
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