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Progress in Modern Biomedicine. 2018, (23)

Centrosome Inheritance Patterns in Human Gametes and Early Embryos and its Significance in Assisted ReproductionChinese Full Text

ZHOU Qin-wei;XU Li;WEI Dan;XIE Qi;GU Yi-fan;Institute of Reproductive and Stem Cell Engineering,Central South University;Reproductive and Genetic Hospital of CITIC-XIANGYA;

Abstract: The centrosome is composed of pericentriolar material（PCM） surrounding a pair of perpendicular cylinder centriole.Centrosome is known as major microtubule organizing center（MTOC） in mammalian cells and plays an important role in cell division.The centrosome is replicated in a semi-reserved form. The centrosome reduction occurs during the process of spermiogenesis and oogenesis. The Sperm and oocyte retain the part of the centrosome and reconstitute the functional integrity centrosome after fertilization. The defects of sperm centrosome will lead to maleinfertility, and the aging of oocyte also results in abnormal spindle structure due to the defects of centrosomal protein and causes abnormalities in fertilization and early embryonic development. The centrosome structure and function crucial in human fertilization and embryo development, and also show great significances in human assisted reproduction.
Keywords：

Centrosome; Human; Sperm; Oocyte; Embryo;

  • DOI：

    10.13241/j.cnki.pmb.2018.23.043

  • Series：

  • Subject：

  • Classification Code：

    R714.8

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