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Chinese Journal of Clinical Obstetric and Gynecology. 2001, (06)

Tbe clinical significance of the serum CA125 level in ovarian cancerChinese Full Text

ZHENG Hong, YANG Yanbin,LIU Zhaohui, et al (Department of Gynecology and Obstetrics, Hie First Hospital Peking University, Beijing 100034, China)

Abstract: Objective To evaluate the clinical significance of the serum CA125 level before and after operation of ovarian cancer. Methods 137 patients with ovarian cancer underwent operation in First hospital between January 1994 and August 2000. Correlation analyes among the serum CA125 level and histological type, FTCO stage, cell differentiation, extent of cytoreduc-tion, number of chemotherapy courses, time of recurrence and survival rate were carried out retrospectively. Results The serum CA125 level before operation was related to histological type and FIGO stage （P= 0.006） . The level at 2-4 months after operation was related to the extent of cytoreduction （ P = 0.025） . The level at 5 - 7 months after operation was related to the number of chemotherapy courses and It was also the independent prognostic variable. The increase of the serum CA125 level after operation usually indicated recurrence with asensitivity of 87.5% and the change often occurred 7.2 months （in average） than clinical recurrence. Conclusions The serum CA125 level before operation of ovarian cancer can help to know the histological type and FIGO stage. This marker is useful in the early detection of recurrence. Monitoring it changes after operation can provide the information about the extent of cytoreduction and predict time of recurrence and survival rate.
Keywords：

CA125; Ovarian neoplasms;

  • DOI：

    10.13390/j.issn.1672-1861.2001.06.008

  • Series：

  • Subject：

  • Classification Code：

    R737.31

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