Identification of Metabolites of Resveratrol in Rat Urine and Bile Using LC-MS-MSChinese Full Text
HUANG Hui-lian;YAO Shun;HUANG Xiao-ying;LIANG Yong-hong;SHAO Feng;REN Gang;LIU Rong-hua;Jiangxi University of Traditional Chinese Medicine;Department of Pharmaceutical and Biological Engineering,Sichuan University;
Abstract: Objective: Identified the metabolites of resveratrol in vivo. Method: A method using liquid chromatography-electrospray ionization tandem mass spectrometry（ LC-MS-MS） analysis was established for the identification of metabolites of resveratrol. The rat urine and bile samples were pretreated by solid-phase extraction（ SPE） method after oral administration at a dose of 100 mg·kg- 1of resveratrol. Result: Five metabolites were identified on their MS fragmentation behaviors by LC-MS-MS method with electrospray ionization（ ESI） in negative ion mode. Conclusion: The results indicated the method could be used to rapid screen and identify the conceivable structures of active components responsible for pharmacological effects of resveratrol.
Keywords：
- DOI：
10.13422/j.cnki.syfjx.2014140056
- Series：
- Subject：
- Classification Code：
O657.63;R285.5
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