Antitumor Effects of Different Polarity Extracts from The Kaki Folium on Hepatoma H22 and Sarcoma H22,S180 Bearing MiceChinese Full Text
CHEN Li;ZHANG An-wen;LUO Yu;FENG Yi-ping;LIANG Yu-hong;Guangxi University of Science and Technology;Liuzhou Worker’s Hospital;
Abstract: Objective:To observe the antitumor effects of different polarity extracts from Kaki Folium on hepatoma H22 and sarcoma S180 bearing mice.Method:The the Kaki Folium were successively extracted with ethanol,chloroform,ethyl acetate and n-butanol,the ethanol extraction were extracted by water,and the different polarity extracts were obtained.Experimental H22 ascites tumor mice model,H22 and S180 solid tumor mice models were established,respectively.The experimental mice were randomly divided into a series of groups:blank control group,model group,cyclophosphamide group,low-,middle-and high-dosage groups of the various different polarity extracts.The mice were intragastrically administrated the corresponding drugs for 10 days.The abdominal circumference,inhibition rate of ascites and liver tissue physiological form were observed in H22 ascites tumor mice.The food intake,body weight,tumor inhibition rate,life prolongation rate,values of thymus coefficient and spleen coefficient were recorded.Result:Compared with the model group,the volume of ascites and ameliorate liver cell swelling,karyolysis on H22 ascites tumor mice were significantly reduced in ethyl acetate extract,water extract and n-butanol extract groups,while no significant effects on food intake and body weight in H22,S180 solid tumor mice were found.The tumor inhibition rate,life prolongation rate,values of thymus coefficient and spleen coefficient were significantly increased（P ＜ 0.01 or P ＜ 0.05） after treated with different polarity extracts and cyclophosphamide groups.Conclusion:The ethyl acetate extract,water extract and n-butanol from Kaki Folium possess have certain antitumor effects on hepatoma H22 and sarcoma S180 bearing mice,which may be the effective fractions of antitumor effects from persimmon leaves.The ethyl acetate-extracted fraction has better effects on hepatoma H22 bearing mice（included the solid and ascites tumor） than sarcoma S180 bearing mice.
- DOI：
10.13422/j.cnki.syfjx.2015010167
- Series：
- Subject：
- Classification Code：
R285.5
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