Medicinal Properties of Chemical Components in Daturae Flos Based on Effects on Relevant Indicators of Autonomic Nervous SystemChinese Full TextEnglish Full Text (MT)
LI Zhen-yu;WANG Qiu-hong;YANG Bing-you;SHU Zun-peng;KUANG Hai-xue;Key Laboratory of Chinese Materia Medica,Heilongjiang University of Chinese Medicine,Ministry of Education,Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material Bases;
Abstract: Objective: To clarify the medicinal properties of chemical components in Daturae Flos,and provide scientific basis for the objectivity of new hypothesis theory "One flavor and one property for Chinese medicine,X flavors and Y properties for one medicine（ Y≤X） ". Method: Male Kunming mice and Wistar rats were randomly divided into normal group,Daturae Flos decoction group,alkaloid components high dose group,low dose group,macroporous resin 50% ethanol elution components high dose group and low dose group. The mice were treated by intragastric administration and the mice in normal group received same volume of normal saline,1time a day for consecutive 10 days. The effects of Daturae Flos and its chemical components on heart rate,breathing rate,blood pressures, the amount of salivary secretory and body temperature relative to autonomic nervous system were observed as part of the medicinal properties evaluation of Daturae Flos for further research.Result: Compared with the normal group,the Daturae Flos and its alkaloid components had certain effect or effect trend in increasing the heart rate of mice,accelerating the breathing rate of rats,increasing the mean arterial blood pressure in rats,inhibiting salivary secretory in mice and increasing body temperature of rats（ P ＜ 0. 05,P ＜ 0. 01）. Macroporous resin 50% ethanol elution components could promote salivary secretory in mice,and have certain effect on reducing heart rate of mice and reducing breathing rate of rats（ P ＜ 0. 05,P ＜ 0. 01）,but with no significant effect on mean arterial blood pressure or body temperature in rats. There was certain difference or statistically significant difference between macroporous resin 50% ethanol elution components and alkaloid components in effects on heart rate of mice,breathing rate of rats,mean arterial blood pressure in rats,salivary secretory in mice and body temperature of rats（ P ＜ 0. 05,P ＜ 0. 01）. Conclusion: Daturae Flos and its alkaloid components have warm medicinal properties,while macroporous resin 50% ethanol elution components have cold medicinal properties based on the results and previous research results.
- DOI：
10.13422/j.cnki.syfjx.2016090086
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- Classification Code：
R285.5
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