The Molecular Mechanisms of Mitochondrial Unfolded Protein ResponseChinese Full TextEnglish Full Text (MT)
FAN Yu-Mei;HAO Qiang;LIU Si-Ying;CHANG Yan-Zhong;DUAN Xiang-Lin;TAN Ke;Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province,College of Life Science, Hebei Normal University;
Abstract: As newly found cellular stress response, the mitochondrial unfolded protein response(UPRmt) is associated with the pathological process of aging, cancer and neurodegenerative diseases. To maintain mitochondrial protein homeostasis, cell will inspire UPRmtprogram by activating the transcription of mitochondrial chaperones and proteases encoded by nuclear DNA. Exploring the mechanisms of UPRmtis essential for understanding the pathological process of aging and mitochondria-related diseases. In this review, we focus on various inducers of UPRmt, the different mechanisms of UPRmt, the regulatory factors, and relationship with aging,immunity and other diseases in C. elegans and mammalian cells to provide new theoretical basis and therapeutic target for these diseases.
- DOI：
10.16476/j.pibb.2016.0385
- Series：
- Subject：
- Classification Code：
Q51
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