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Chinese Journal of Immunology. Core
(Accepted Version) Online First Publishing Date: 2021-12-02 17:53:07

Bioinformatics analysis on structure and function of the SARS-CoV-2 receptor protein ACE2 and its prokaryotic expressionrevokeChinese Full Text

LIU Ling;CHEN Xiao-Cong;XUAN Yan;DU Miao;FAN Lei;LI Zhuo-Xi;LI Jing;XU Ben-Jin;SONG Bin-Yu;HOU Yan-xiang;

Abstract: Human ACE2 is the cell surface receptor of SARS-CoV-2. The prokaryotic expression vector of ACE2 was constructed， and its structure and function were analyzed by bioinformatics to explore the molecular mechanism of SARS-CoV-2 invasion into human body. In this paper， the physicochemical properties， subcellular localization， post-translational modification and interaction network of ACE2 protein were systematically analyzed by using online software and databases such as Protparam， ProtScale， NetPh... More
Keywords：

SARS-CoV-2; Vector construction; ACE2 protein; Bioinformatics analysis; Prokaryotic expression;

  • Series：

    (A) Mathematics/ Physics/ Mechanics/ Astronomy; (E) Medicine ＆ Public Health

  • Subject：

    Biology; Fundamental Medicine

  • Classification Code：

    R373

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