Mammalian transgenerational inheritance of acquired traits via germline transmissionChinese Full TextEnglish Full Text (MT)
SHI Jun-Chao;CHEN Qi;DUAN En-Kui;State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences;University of Chinese Academy of Sciences;
Abstract: Increasing evidence indicates that certain parental environmental exposures, such as chemical contact, diet change and mental stress can be "memorized" and passed to future generations, suggesting epigenetic inheritance via germline. Such phenomenon raised significant interests and led to a resurrected interests to the once heretical concept of "Lamarckism". The potential "epigenetic carriers" in the germline include DNA methylation, chromatin structure/histone modifications and noncoding RNAs, further elucidating the molecular mechanism of transgenerational inheritance via mammalian germline would have a profound impact on our understanding of many modern disease etiology.
- DOI：
10.13376/j.cbls/2017002
- Series：
- Subject：
- Classification Code：
Q953
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