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Journal of Third Military Medical University. 2014, (11) Core

Kaempferol vs lindley euqatorium herb total flavonoid for lyperlipemia and hemorheological parameters in ratsChinese Full Text

He Haixia;Kong Lingxi;Li Xiuying;Zhou Yua;Department of Pharmacy,First Affiliated Hospital,Chongqing Medical University;

Abstract: Objective To determine the effect of kaempferol on experimental hyperlipemia and hemorheological parameters in rats,and compare the effect with that of lindley euqatorium herb total flavonoid.Methods A total of 70 SD rats were randomly and equally divided into 7 groups,that is,blank control,hyperlipemia group,high-and low-dosed kaempferol groups,high-and low-dosed total flavonoid groups,and positive drug group（fenofibrate）.The rats of the later 6 groups were fed with high-fat food for 6 weeks,and those of the treatment groups were given oral administration of 300 and 100 mg /kg kaempferol,100 and 50 mg /kg crude total flavonoids,and 20 mg /kg fenofibrate respectively.After 6 weeks,all experimental rats were killed,and the serum levels of blood lipids and hemorheological parameters,the activity of SOD,the content of MDA were detected.Oil red O staining was employed to observe the effects of kaemferol on oxLDL-induced macrophage foam cell formation.Results Kaempferol decreased the serum levels of blood lipids and hemorheological parameters,blood viscosity,and serum content of MDA,but increased the activity of SOD when compared with hyperlipemia group（P ＜ 0.01）.There was no obvious difference in above indexes between the high-and lowdosed total flavonoid groups（P ＞ 0.05）.Kaempferol effectively inhibited oxLDL-induced lipid aggregation within macrophages.Conclusion Consecutive treatment of kaempferol decreases blood lipids,hemorheological parameters,and MDA content,but improves SOD activity.Kaempferol also inhibits the formation of macrophage foam cells.Kaempferol might substitute for lindley euqatorium herb total flavonoid in decreasing blood lipids and anti-inflammation in clinical practice.
Keywords：

kaempferol; lindley euqatorium herb total flavonoid; blood lipids; hemorheology;

  • DOI：

    10.16016/j.1000-5404.2014.11.004

  • Series：

  • Subject：

  • Classification Code：

    R285.5

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