Chemical Constituents and Antipyretic Effect of Eupatorium lindleyanum DC.Chinese Full Text
CHU Chun-jun;REN Hui-ling;WU Tian-wei;ZHANG Jian;College of Pharmaceutical Science,Soochow University;
Abstract: In this study,chemical composition of the ethanol extract of Eupatorium lindleyanum DC. was analyzed by UPLC / Q-TOF-MS. Six compounds were isolated from E. lindleyanum. These compounds were identified as vanillic acid（ 1）,n-octacosanoic acid（ 2）,β-sitosterol（ 3）,daucosterol（ 4）,linarin（ 5）,5,8,4’-trihydroxy-7,3’-dimethoxy flavone（ 6）. Compound 2,5 and 6 were obtained from this plant for the first time. In addition,the antipyretic effect and mechanism of E. lindleyanum on LPS-induced febrile response in rats was observed and elucidated. After the LPS challenge,the temperature of rats was recorded every 30 min,it lasted for 6 h,and then 7 h,8 h. Myeloperoxidase（ MPO） activities in liver tissues was examined,the levels of inflammatory cytokine tumor necrosis factor-α（ TNF-α） and interleukin-6（ IL-6） in serum were measured using ELISA. As a result,the rats of model group showed obvious three-phase fever and the heating peak value（ 1. 97 ℃） appeared at 4 h. The ethanol extract of E. lindleyanum（ EUP-Et OH） significantly decreased the body temperature of rats,and at 8 h following LPS challenge effectively inhibited MPO activity in liver tissues,TNF-α and IL-6 levels in serum.
- DOI：
10.16333/j.1001-6880.2015.05.012
- Series：
- Subject：
- Classification Code：
R284
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