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Chinese Journal of Infection and Chemotherapy. 2017, (05) Core

CHINET surveillance of bacterial resistance across China:report of the results in 2016Chinese Full TextEnglish Full Text (MT)

HU Fupin;GUO Yan;ZHU Demei;WANG Fu;JIANG Xiaofei;XU Yingchun;ZHANG Xiaojiang;ZHANG Zhaoxia;JI Ping;XIE Yi;KANG Mei;WANG Chuanqing;WANG Aimin;XU Yuanhong;SHEN Jilu;SUN Ziyong;CHEN Zhongju;NI Yuxing;SUN Jingyong;CHU Yunzhuo;TIAN Sufei;HU Zhidong;LI Jin;YU Yunsong;LIN Jie;SHAN Bin;DU Yan;GUO Sufang;WEI Lianhua;ZOU Fengmei;ZHANG Hong;WANG Chun;HU Yunjian;AI Xiaoman;ZHUO Chao;SU Danhong;WANG Ruizhong;FANG Hua;YU Bixia;ZHAO Yong;GONG Ping;GUO Dawen;ZHAO Jinying;LIU Wenen;LI Yanming;JIN Yan;SHAO Chunhong;WEN Kaizhen;ZHANG Yirong;XU Xuesong;YAN Chao;YU Hua;HUANG Xiangning;WANG Shanmei;CHU Yafei;ZHANG Lixia;MA Juan;ZHOU Shuping;ZHOU Yan;ZHU Lei;MENG Jinhua;Institute of Antibiotics, Huashan Hospital, Fudan University;

Abstract: Objective To investigate the susceptibility profile of clinical isolates collected from hospitals across China. Methods Twenty-six general hospitals and four children’s hospitals were involved in this program. Antimicrobial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method or automated systems. Results were analyzed according to CLSI 2016 breakpoints. Results A total of 153 059 clinical isolates were collected from Junuary to December 2016, of which gram-negative organisms and gram-positive cocci accounted for 71.6% and 28.4%, respectively. The overall prevalence of methicillin-resistant strains was 38.4% in S. aureus（MRSA） and 77.6% in coagulase negative staphylococcus（MRCNS）, respectively. The resistance rates of methicillin-resistant strains to most of other antimicrobial agents were much higher than those of methicillin-susceptible strains. However, 92.3% of the MRSA strains were still sensitive to trimethoprim-sulfamethoxazole, while 86.5% of the MRCNS strains were susceptible to rifampin. No staphylococcal strains were found resistant to vancomycin or teicoplanin. The resistance rates of E. faecalis strains to most drugs tested（except chloramphenicol） were much lower than those of E. faecium. A few strains of both species were resistant to vancomycin. Vancomycin resistant E. faecalis and E. faecium strains were mainly Van A, Van B or Van M type based on their phenotype or genotype. Regarding the non-meningitis S. pneumoniae strains, the prevalence of PSSP or PISP strains isolated from children was higher than that isolated in 2015, but the prevalence of PRSP strains decreased. However, the prevalence of PISP and PRSP strains isolated from adults was lower than that isolated in 2015. The prevalence of ESBLs-producing strains was 45.2% in E. coli, 25.2% in Klebsiella spp.（K. pneumoniae and K. oxytoca） and 16.5% in Proteus mirabilis isolates on average. ESBLs-producing Enterobacteriaceae strains were more resistant than non-ESBLs-producing strains in terms of antibiotic resistance rate. The strains of Enterobacteriaceae were still highly susceptible to carbapenems. Overall, less than 10% of these strains were resistant to carbapenems. About 68.6% and 71.4% of Acinetobacter spp.（A. baumannii accounts for 90.6%） strains were resistant to imipenem and meropenem, respectively. The prevalence of extensively-drug resistant strains in P. aeruginosa was higher than that in 2015. Conclusions Bacterial resistance to commonly used antibiotics is still on the rise. It is necessary to strengthen hospital infection control and management of clinical use of antimicrobial agents, and maintain good practice in surveillance of bacterial resistance.
Keywords：

bacterial resistance surveillance; antimicrobial susceptibility testing; extensively-drug resistant bacterium; vancomycin-resistant Enterococcus; methicillin-resistant Staphylococcus; penicillin-resistant Streptococcus pneumoniae; carbapenem-resistant gram-negative bacterium;

  • DOI：

    10.16718/j.1009-7708.2017.05.001

  • Series：

  • Subject：

  • Classification Code：

    R446.5

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